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Publications

Shannon, M., Pineau, J., Griffie, J., Aaron, J., Peel, T., Williamson, D., Zamoyska, R., Cope, A., Cornish, G., and Owen, D. (2019)  Differential nanoscale organisation of LFA-1 modulates T cell migration.  J. Cell Sci. doi: 10.1242/jcs.232991 (PDF) .

Stubb, A., Guzman, C., Närvä, E., Aaron, J. Chew, T.-L., Saari, M., Miihkinen, M., Jacquemet, G., and Ivaska, J. (2019) Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells.  Nat. Comm. In Press.

Sato, Y., Hilbert, L., Oda, H., Wan, Y., Heddleston, J.M., Chew, T.-L., Zaburdaev, V., Keller, P., Lionnet, T., Vastenhouw, N., and Kimura, H. (2019) Histone H3K27 acetylation preceding active transcription during zebrafish zygotic genome activation as revealed by live cell analysis. Development. In Press.

O'Shaughnessy, E., Stone, O., LaFosse, P., Azoitei, M., Tsygankov, D., Heddleston, J.M., Legant, W., Burridge, K., Elston, T., Betzig, E., Chew, T.-L., Adalsteinsson, D., and Hahn, K. (2019) Software for lattice light-sheet imaging of FRET biosensors, illustrated with a new Rap1 biosensor. J. Cell Bio. In Press.

Faust, J.J., Balabiyev, A., Heddleston, J.M., Podolnikova, N.P., Baluch, D.P., Chew, T.-L., and Ugarova, T.P. (2019) An actin-based protrusion originating from a podosome-enriched region initiates macrophage fusion. MBoC. doi: 10.1091/mbc.E19-01-0009 (PDF)

Colin-York, H., Javanmardi, Y., Barbieri, L., Li, D., Korobchevskaya, K., Guo, Y., Hall, C., Taylor, A., Khuon, S., Sheridan, G.K., Chew, T-L., Li, D., Moeendarbary, E., and Fritzsche, M. (2019). Spatiotemporally super-resolved volumetric traction force microscopy. Nano Lett. doi: 10.1021/acs.nanolett.9b01196 (PDF)

Klomp, J.E., Shaaya, M., Matsche, J., Rebiai, R., Aaron, J.S., Collins, K.B., Huyot, V., Gonzalez, A.M., Muller, W.A., Chew, T.-L., Malik, A.B., Karginov. A.V. (2019). Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response. Cell Chem. Biol. (26) doi: 10.1016/j.chembiol.2019.04.007 (PDF)

Quinney, K., Frankel, E., Shankar, R., Kasberg, W., Luong, P., and Audhya, A. (2019). Growth factor stimulation promotes multivesicular endosome biogenesis by prolonging recruitment of the late-acting ESCRT machinery. PNAS. (14). doi: 10.1073/pnas.1817898116 (PDF)

Aaron, J., Wait, E., DeSantis, M., and Chew, T-L. (2019). Practical considerations in particle and object tracking and analysis. Current Protocols in Cell Biology. doi: 10.1002/cpcb.88 (PDF)

Tamzalit, F., Wang, M.S., Jin, W., Tello-Lafox, M., Boyko, V., Heddleston, J.M., Black, C.T., Kam, L.C., Huse, M. (2019). Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells. Sci. Immunol. (4). (PDF)

Barger, S., Reillly, N., Shutova, M., Li, Q., Maiuri, P., Heddleston, J.M., Mooseker, M., Flavell, R., Svitkina, T., Oakes, P., Krendel, M., and  Gauthier, N. (2019). Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis. Nat. Comm. (10). doi: 10.1038/s41467-019-09104-1 (PDF)

Billaudeau, C., Yao, Z. Cornilleau, C., Carballido-Lopez, R., Chastanet, A. (2019). MreB forms subdiffraction nanofilaments during active growth in Bacillus subtilis. mBio 10(1). doi: 10.1128/mBio.01879-18 (PDF)

Yi, J., Balagopalan, L., Nguyen, T., McIntire, K.M., Samelson, L.E. (2019) TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps. Nat. Comm. (10). doi: 10.1038/s41467-018-08064-2 (PDF)

Kreutzberger, A. J., Ji, M., Aaron, J., Mihaljević, L., & Urban, S. (2019). Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion. Science, 363(6426), doi: 10.1126/science.aao0076. (PDF)

Phillips, J. K., Sherman, S. A., Cotton, K. Y., Heddleston, J. M., Taylor, A. B. and Finan, J. D. (2019) Characterization of neurite dystrophy after trauma by high speed structured illumination microscopy and lattice light sheet microscopy. J. Neurosci. Methods. 312: 154-61. doi: 10.1016/j.jneumeth.2018.12.005. (PDF)

 

Peters, R., Griffie, J., Williamson, D., Aaron, J., Khuon, S., Owen, D., (2019) Development of 2-colour and 3D SMLM data analysis methods for fibrous spatial point patterns. J. Phys. D 52 014005 (PDF)

Wang, H., Rivenson, Y., Jin, Y., Wei, Z., Gao, R., Günaydin, H., Bentolila, L.A., Kural, C., Aydogan, O. (2018) Deep learning enables cross-modality super-resolution in fluorescence microscopy. Nat. Meth. doi: 10.1038/s41592-018-0239-0. (PDF)

Bertiaux, E., Mallet, A., Fort, C., Blisnick, T., Bonnefoy, S., Jung, J., Lemos, M., Marco, S., Vaughan, S., Trépout, S., Tinevez, J.Y., Bastin, P. (2018) Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum. J. Cell Bio. doi: 10.1083/jcb.201805030 (PDF)

Aaron J., Chew TL. (2018) Analysis of Image Similarity and Relationship. In: Jerome W., Price R. (eds) Basic Confocal Microscopy. Springer, Cham (PDF)

Condon, N.D., Heddleston, J.M., Chew, T.L., Luo, L., McPherson, P.S., Ioannou, M.S., Hodgson, L., Stow, J.L., Wall, A.A. (2018) Macropinosome formation by tent pole ruffling in macrophages. J. Cell Bio. doi: 10.1083/jcb.201804137 (PDF)

Padilla-Rodriguez, M.,  Parker, S.S., Adams, D.G., Westerling, T., Puleo, J.I., Watson, A.W., Hill, S.M., Noon, M., Gaudin, R., Aaron, J., Tong, D., Roe, D.J., Knudsen, B., Mouneimne, G. (2018) The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion. Nat. Comm. 9(2980) 1-16. doi: 10.1038/s41467-018-05367-2 (PDF)

Balagopalan, L., Yi, J., Nguyen, T., McIntire, K.M., Harned, A.S., Narayan, K., Samelson, L.E. (2018) Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation. Nat. Comm. 9(2013) 1-17. doi: 10.1038/s41467-018-04419-x (PDF)

Buttler, C.A., Pezeshkian, N., Fernandez, M.V., Aaron, J.S., Norman, S., Freed, E.O., van Engenlenburg, S.B. (2018). Single molecule fate of HIV-1 Envelope reveals late-stage viral lattice incorporation. Nat. Comm. 9(1) 1861-76. doi: 10.1038/s41467-018-04220-w (PDF)

Faust, J.J., Christenson, W., Doudrick, K., Heddleston, J.M., Chew, T.L., Lampe, M., Balabiyev, A., Ros, R., and Ugarova, T.P. (2018). Fabricating optical-quality glass surfaces to study macrophage fusion. J. Vis. Exp. (133)., doi: 10.3791/56866 

Taylor, A.B., Ioannou, M.S., Aaron, J., Chew, T.L. (2018). Model-free quantification and visualization of colocalization in fluorescence images. Cytometry Part A. doi: 10.1002/cyto.a.23356 (PDF)

 

Moore, T.I., Aaron, J., Chew, T.L., Springer, T.A. (2018). Measuring integrin conformational change on the cell surface with super-resolution microscopy. Cell Reports, 22 (7). 1903-12. Doi: 10.1016/j.celrep.2018.01.062 (PDF)

McArthur, K., Whitehead, L.W., Heddleston, J.M., Li, L., Padman, B.S., Oorschot, V., Geoghegan, N.D., Chappaz, S., Davidson, S., Chin, H.S., Lane, R.M., Dramicanin, M., Saunders, T.L., Sugiana, C., Lessene, R., Osellame, L.D., Chew, T.L., Dewson, G., Lazarou, M., Ramm, G., Lessene, G., Ryan, M.T., Rogers, K.L., van Delft, M.F., and Kile, B.T. (2018). BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.  Science, 359. doi: 10.1126/science.aao6047 (PDF)

 

Matsubayashi, Y., Louani, A., Dragu, A., Sanchez-Sanchez, B.J., Serna-Morales, E., Yolland, L., Gyoergy, A., Vizcay, G., Fleck, R.A., Heddleston, J.M., Chew, T.L., Siekhaus, D.E., and Stramer, B.M. (2017). A moving source of matrix components is essential for de novo basement membrane formation. Current Biology, 27 (22). 3526-34. Doi: 10.1016/j.cub.2017.10.001(PDF)

 

Mass, T., Drake, J.L., Heddleston, J.M., Falkowski, P.G. (2017). Nanoscale visualization of biomineral formation in coral proto-polyps.  Current Biology, 27 (20). 3191-96. Doi: 10.1016/j.cub.2017.09.012 (PDF)

 

Aaron, J.S., Taylor, A.B., Chew, T.L. (2017). Image co-localization: co-occurrence versus correlation. J. Cell Sci., 131 (3). Doi: 10.1242/jcs.211847 (PDF)

Taylor, A.B. Ioannou, M.S. Watanabe, T., Hahn, K. and Chew, T.L. (2017). Perceptually accurate display of two greyscale images as a single colour image.  J. Microscopy, 268(1), 73 - 83. (PDF)

Fritzsche M, Fernandes RA, Chang VT, Colin-York, H., Clausen, M.P., Felce, J.H., Galiani, S., Erlenkamper, C., Santos, A.M., Heddleston, J.M., Pedroza-Pacheco, I., Waithe, D., Bernardino de la Serna, J., Lagerholm, B.C., Liu, T.L., Chew, T.L., Betzig, E., Davis, S.J., and Eggeling, C. (2017).  Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation.  Science Advances, 3(6), 1 - 18. (PDF)

Griffié, J., Shlomovich, L., Williamson, D. J., Shannon, M., Aaron, J., Khuon, S., Burn, G. L., Boelen, L., Peters, R., Cope, A. P., Cohen, E. A. K., Rubin-Delanchy, P., Owen, D. M. (2017). 3D Bayesian cluster analysis of super-resolution data reveals LAT recruitment to the T cell synapse. Scientific Reports, 7(1), 1 - 9. (PDF)

Ashdown, G. W., Burn, G. L., Williamson, D. J., Pandžić, E., Peters, R., Holden, M., Ewers, H., Shao, L., Wiseman, P. W., Owen, D. M. (2017). Live-Cell Super-resolution Reveals F-Actin and Plasma Membrane Dynamics at the T Cell Synapse. Biophysical J., 112(8), 1703 - 1713. (PDF)

Chew, TL, George, R., Soell, A and Betzig, E. (2017) Advanced Imaging Center and lattice light sheet microscope: Opening a path to commercialization. Optics and Photonics News July/August 2017, 42-49. (PDF)

Crowe, L. B., Hughes, P. F., Alcorta, D. A., Osada, T., Smith, A. P., Totzke, J., Loiselle, D.R., Lutz, I.D., Gargesha, M., Roy, D., Roques, J., Darr, D., Lyerly, H.K., Spector, N.L., and Haystead, T.A.J. (2017). A fluorescent Hsp90 probe demonstrates the unique association between extracellular Hsp90 and malignancy in vivo. ACS Chem. Biol., 12(4), 1047 - 1055. (PDF)

Carr, L., Bardet, S. M., Burke, R. C., Arnaud-Cormos, D., Leveque, P., and O'Connor, R. P. (2017). Calcium-independent disruption of microtubule dynamics by nanosecond pulsed electric fields in U87 human glioblastoma cells. Scientific Reports, 7(41267), 1 – 12. (PDF)

Hu, S., Dasbiswas, K., Guo, Z., Tee, Y.-H., Thiagarajan, V., Hersen, P.,Chew, T.L., Safran, S.A., Zaidel-Bar, R., and Bershadsky, A.D. (2017). Long-range self-organization of cytoskeletal myosin II filament stacks. Nature Cell Biol., 19(2), 133 – 141. (PDF)

Abdu, Y., Maniscalco, C., Heddleston, J. M., Chew, T.-L., and Nance, J. (2016). Developmentally programmed germ cell remodelling by endodermal cell cannibalism. Nature Cell Biol., 18(12), 1302 - 1310. (PDF)

Heddleston, J. M., and Chew, T.-L. (2016). Light sheet microscopes: Novel imaging toolbox for visualizing life's processes. The International J. Biochem. & Cell Biol., 80, 119 - 123. (PDF)

Hookway, C., Ding, L., Davidson, M. W., Rappoport, J. Z., Danuser, G., and Gelfand, V. I. (2015). Microtubule-dependent transport and dynamics of vimentin intermediate filaments. Mol. Biol. Cell, 26(9), 1675 - 1686. (PDF)

Xiao, Y., Faucherre, A., Pola-Morell, L., Heddleston, J. M., Liu, T.L., Chew, T.L., Sato, F., Sehara-Fujisawa, Kawakami, K., and Lopez-Schier, H. (2015). High-resolution live imaging reveals axon-glia interactions during peripheral nerve injury and repair in zebrafish. Disease Models & Mechanisms, 8(6), 553 - 564. (PDF)